KDM5C and X-linked intellectual disability: Lysine demethylase 5C (Kdm5c) is frequently mutated in patients with X-linked intellectual disabilities, many of whom exhibit physical and behavioral abnormalities, including epilepsy, short stature, etc. 4In our previous study, we investigated the de-differentiated MSCs with enhanced osteogenic differentiation capacity and found that Kdm5c might be involved in regulating the properties of dedifferentiated osteogenic MSCs by PCR array.5