After reviewing the molecular profiles of 52,426 tumor samples from 21 cancer types, Heeke AL et al identified the frequencies of pathogenic mutations in HR-DDR genes (ARID1A, ATM, ATRX, BAP1, BARD1, BLM, BRCA1/2, BRIP1, CHEK1/2, FANCA/C/D2/E/F/G/L, MRE11A, NBN, PALB2, RAD50, RAD51, RAD51B, and WRN). This evidence concerns the gene PALB2 and cancer.