The results showed that overexpression of RNF6 increased VIM protein, in contrast, knockdown or knockout of RNF6 by its specific shRNA or sgRNA brought down VIM protein in both K562 and KMB5, two typical CML cell lines (Fig. 1C, D; Fig. S1A, B). The gene discussed is VIM; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.