To find out the effects of RNF6 on VIM activity, we knocked down or overexpressed RNF6 in CML cells, and the subsequent IB analysis revealed that RNF6 up-regulated VIM, along with its Ser39 phosphorylation (Fig. S4A, B). The gene discussed is RNF6; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.