VIM and neoplasm: To find out the specific protein substrates of RNF6 in CML cells, we performed an affinity-purification coupled LC/MS/MS assay and found that vimentin (VIM), a major constituent of the intermediate filament family of proteins and a key regulator of tumor growth, invasion, and poor prognosis,3 is an interacting partner of RNF6 which was further confirmed in CML and HEK293T cells (Fig. S1A, B; Fig. 1A, B).