PRR TLR adjuvants used in vaccines include agonists of TLR9 (CpG oligodeoxynucleotides (ODN)) - the hepatitis B virus vaccine Heplisav-B, MGN1703 for cancer vaccines; TLR3 (poly-IC/ICLC derivates (Ampligen® Hiltonol®)) for cancer and HIV vaccines, TLR4 (monophosphoryl lipid A derivative agonist AS04, for Cervarix (human HPV)/Hep B (Fendrix®), AS01 for the herpes zoster vaccine Shingrix®, glucopyranosyl Lipid A for influenza vaccines), TLR 5 agonists (flagellin derivatives such as Mobilan or entolimod) or TLR7 (resiquimod (an imidazoquinoline) employed with cancer vaccines (42). This evidence concerns the gene TLR4 and cancer.