SFN and hepatocellular carcinoma: To explore the biological function of SFN in the progression of HCC, we upregulated SFN expression by lentivirus-mediated ectopic expression in SMMC-7721 (named SMMC-7721-Lv-SFN) cells, with the lowest SFN expression level, and we downregulated SFN expression by lentivirus-mediated knockdown in MHCC-97H (named MHCC-97H-Lv-shSFN) cells, with the highest SFN expression level.