It is worth noting that IFNγ is also a cytokine documented to upregulate the expression of PD‐L1 in tumor cells.[38] Herein, we observed that IFNγ increased the expression of GSDMB and PD‐L1, suggesting that the combination of pyroptosis inducers and immune checkpoint inhibitors may be able to maximize the effect of killing tumor cells. This evidence concerns the gene GSDMB and neoplasm.