ERBB2 and neoplasm: The GSDMB gene and ERBB2 gene are located at the ERBB2/NEU locus (17q12‐21), and the amplification of ERBB2 leads to the amplification of GSDMB (Figure S11, Supporting Information).[40, 41, 42] Indeed, this is tantamount to installing a “bomb” for tumor cells; IBI315 bridges tumor cells and T cells and acts as the “fuse” that detonates the bomb, which induces pyroptosis of tumor cells and further activates and recruits more immune cells, causing a local inflammatory response.