GSDMB encompasses six distinct isoforms and emerging evidence highlights the indispensability of exon 6 translation in facilitating GSDMB‐mediated pyroptosis.[18, 26, 27, 28, 29] Consequently, an intriguing avenue for future research in our study pertains to elucidating the specific isoform(s) of GSDMB that IBI315 mediates, leading to the generation of the N‐terminal fragment implicated in tumor cell pyroptosis. The gene discussed is GSDMB; the disease is neoplasm.