CD274 and neoplasm: They found that pyroptosis increased the expression of immune activation‐related genes such as CD69, granzyme A (GZMA), and granzyme B (GZMB), while it decreased the immune‐suppression‐related genes such as CSF1, vascular endothelial growth factor A (VEGFA), and CD274.[31] Another study found that methotrexate‐induced pyroptosis activated macrophages and recruited neutrophils in tumors, killing tumor cells.[32] Importantly, we found that pyroptosis induced by IBI315 resulted in the release of IL‐18 from tumor cells.