To verify IBI315‐mediated pyroptosis in T cell activation in vivo, we performed flow cytometry analysis on the intratumoral infiltrating lymphocytes of Her2‐positive gastric cancer PDX‐1 and found that compared with the control IgG group, the tumor‐infiltrating CD8+ and CD4+ lymphocytes in the IBI315 treatment group had a higher proportion of Ki67 expression (Figure 5M,N), indicating IBI315 could promote the expansion of CD8+ and CD4+ lymphocytes in tumors. Here, CD8A is linked to neoplasm.