By analyzing the RNA sequencing data of several major GI tumors in the TCGA database, including pancreatic, liver, colon, gastric, esophagus, and bile duct cancers, as well as the corresponding normal tissue data in the GTEx database, we found that TRIM21 was highly expressed in these 6 kinds of GI tumors (Figure 7D‐I). This evidence concerns the gene TRIM21 and digestive system neoplasm.