By analyzing RNA sequencing data from TCGA database and GSE78229 dataset, we found that the “WP_FERROPTOSIS” gene set and “FERRDB_SUPPRESSOR” gene set were enriched in the TRIM21‐high expression group in multiple GI tumors, indicating the potential regulatory role of TRIM21 in ferroptosis in GI tumors (Figure 7L‐O, Figure S6A‐E, Supporting Information). Here, TRIM21 is linked to digestive system neoplasm.