TRIM21 and familial pancreatic carcinoma: Previous studies have noted that TRIM21 is highly expressed in various types of human cancers.[47, 48, 49, 50] To determine the correlation of TRIM21 expression with pancreatic cancer, immunohistochemical (IHC) staining of PDAC tissue microarrays (TMAs) was performed, showing significant upregulation of TRIM21 in PDAC samples compared with paracarcinoma samples (Figure7A, B).