To investigate the potential role of ubiquitination in FSP1 upon ferroptosis induction, human hepatocellular carcinoma cells MHCC‐97H and human pancreatic cancer cells PANC‐1 with stable FSP1 overexpression were transfected with Myc‐Ub and were treated with various ferroptosis inducers, including RSL3, imidazole ketone erastin (IKE), FIN56, and cystine‐deprived culture medium. Here, MYC is linked to hepatocellular carcinoma.