Indeed, we have found that neuron‐derived USP25 contributes to the pathogenesis and development of AD.[16] USP25 promotes the cleavage of amyloid precursor protein (APP) and the generation of amyloid‐β by reducing the ubiquitination and degradation of APP and BACE1, thereby exacerbating AD neuropathology in 5×FAD mice.[16]. Here, USP25 is linked to Alzheimer disease.