TRIM45 and ischemic stroke: A recent study showed that the E3 ligase TRIM45 promoted ischemia‐induced neuronal damage by enhancing microglia‐mediated neuroinflammation.[30] Mechanistically, TRIM45 enhances NF‐κB activation by K63 ubiquitinating TAB2.[30] In good agreement, we found that USP25 alleviated neuroinflammation and ischemic stroke injury by removing K63 polyubiquitin chains from TAB2.