For example, USP25 inhibits experimental autoimmune encephalomyelitis by inhibiting IL‐17‐induced signaling and inflammation.[11] In addition, USP25 is also involved in other inflammation‐associated diseases including sepsis,[12] viral infection,[13] pancreatitis,[14] colitis,[15] and Alzheimer's disease.[16] However, the function of USP25 in stroke has not been studied. Here, USP25 is linked to early-onset autosomal dominant Alzheimer disease.