On 3 d post infection, immune response-related pathways were observed, including pathways of Toll-like receptor (TLR), T cell receptor (TCR), chemokine, TNF and NLR, all of which were mainly related to the significant upregulation of Ikbkg protein (NF-κB essential modulator) (Fig. 5c, Fig. 6a and d). The gene discussed is IKBKG; the disease is infection.