In the old age group (OF v OM), there were many more autosomally encoded DEGs by sex, with markers of disease-associated microglia [21] (i.e., Csf1, Itgax, Cst7) being more highly expressed in old females than old males (as identified in at least one methodology) (Fig. 4H, I, K, L). Here, CST7 is linked to ocular melanoma.