To visualize the influence on the Warburg effect caused by AKR1B10, the changes of differential products (glucose, phosphoenolpyruvate, pyruvate, lactate) involved in the glycolytic pathway were displayed respectively (Fig. 3F), indicating a hyperactive Warburg effect in lung cancer cells with AKR1B10 overexpressed. This evidence concerns the gene AKR1B10 and lung carcinoma.