We further collected the metastasectomy surgical specimens from lung cancer BM patients (n = 29) and assessed the correlation between AKR1B10 and LDHA expression by IHC staining, the data showed a significant positive correlation between AKR1B10 and LDHA (Fig. 5G, H), indicating the existence of AKR1B10-LDHA regulatory axis in lung cancer BM. Here, AKR1B10 is linked to lung cancer.