AKR1B10 and neoplasm: For lung and liver, which are characterized by a high level of oxidative stress and create a challenging microenvironment for metastatic tumor cells due to the high concentrations of oxygen and exposure to toxic compounds, increased AKR1B10 activity could serve to protect tumor cells from oxidative stress-induced damage which impairs the FAO metabolism [43, 44], leading to the a rebalancing of cellular metabolism in glycolysis and fatty acids.