For example, Yu et al. reported that histone Kla drives tumorigenesis by promoting the expression of the m(6)A reading protein YTHDF2 in ocular melanoma [46]; Yang J et al. found that histone Kla promotes the progression of clear cell renal cell carcinoma through activation of platelet-derived growth factor receptor beta (PDGFRβ) transcription [49]; Jiang et al. confirmed that histone Kla regulates the expressions of a series of glycolysis-related enzymes and modulates cellular metabolism in non-small cell lung cancer [50]. Here, YTHDF2 is linked to clear cell renal carcinoma.