After fully adjusting for gender, age, BMI, Etiology of ESRD, history of hypertension, diabetes, CVD, HB, Alb, calcium, phosphorus, iPTH, TC, TG, total Kt/V and eGFR, multivariable analysis revealed that patients in group G2 and G3 carried 137% (HR: 2.37, 95% CI:1.06—5.23, p = 0.035) and 140% (HR: 2.40, 95% CI:1.01—5.69, p = 0.048) higher risk of mortality. The gene discussed is ALB; the disease is diabetes mellitus.