A study performed in Iranian population [61] found that the effect of ABCA1 rs1883025 is only prominent in haplotype rs2422493/rs1800976/rs2230806/rs1883025 carriers, however we performed a binary logistic regression analysis and found that ABCA1 rs1883025 CT genotype is associated with decreased risk for CAD development under overdominant genetic model. This evidence concerns the gene ABCA1 and coronary artery disorder.