BRCA2 and neoplasm: To resolve this aspect of reciprocal pairs, we performed linked-read (LR) and standard WGS on 46 tumours and matched normal samples that were originally found by clinical panel sequencing to have inherited or somatic mutations in BRCA1 (27 cases) or BRCA2 (19 cases; Extended Data Figs. 1 and 4b and Supplementary Note 3).