For example, circ0001785 not only shows higher diagnostic efficiency for breast cancer detection than the two most widely investigated biomarkers serum carcinoembryonic antigen (CEA) and cancer antigen 15-3 (CA15-3) [196], but also possesses strong prognostic potential in predicting the histological grade, TNM (Tumor, Node, Metastasis) stage and distant metastasis in breast cancer progression [196]. The gene discussed is CEACAM5; the disease is breast carcinoma.