Inhibitory effects on glioma proliferation and cell-cycle acceleration are instead mediated by a 185 amino acid protein encoded from circFBXW7 (FBXW7-185aa) which reduces the half life of c-Myc by antagonizing USP28-induced c-Myc stabilization, suggesting new prognostic implications for glioma patients [127]. The gene discussed is USP28; the disease is central nervous system cancer.