In regard to leukemia, Shah et al. synthesized a macroporous cryogel based on methacrylated PEG and alginate (MA-PEG and MA-alginate) to vehiculize a combination of leukemia antigens, CpG-ODN and GM-CSF in AML-bearing mice, resulting in prophylactic T cell-based effects and significant therapeutic antitumor responses when combined with chemotherapy [126]. The gene discussed is CSF2; the disease is leukemia.