By modifying the carboxyl functional groups of γ-PGA-based nano-scale particles with amine moieties, Kim et al. managed to deliver the OVA model antigen and the adjuvant poly(I:C) to the lymph nodes in E.G7-OVA tumor-bearing mice, resulting in an important immune response, with a significant activation of NK-cells and CD8+ T cells, and a subsequent tumor growth inhibition [50]. This evidence concerns the gene CD8A and neoplasm.