Liang et al. synthesized gold nanocages (AuNCs) coated with liposomes to deliver a specific melanoma antigen derived from the tyrosinase-related protein 2 (TRP2) and the adjuvant MPLA to DCs so that they process the antigen and activate CD8 + T lymphocytes, generating an immune response that inhibits tumor growth and metastasis in B16-F10 melanoma animal models. This evidence concerns the gene CD8A and melanoma.