Previous findings that FLT3-ITD-induced acute leukemia (FLT3ITD/ITD; Mx+) shows relative expansion of the Lineage- Sca-1+ Kit+ (LSK) compartment [26] compared to FLT3ITD/ITD; Cre− animals could be recapitulated (3.968 ± 2.055 × 103 BMC in FLT3ITD/ITD; Cre− versus 1.3099 ± 0.3144 × 104 BMC in FLT3ITD/ITD; Mx+; p = 0.0004) (Fig. 4C, D). Here, KIT is linked to acute leukemia.