We demonstrated that inhibiting the expression of hsa-miR-204-5p could reverse the down-regulation of wnt11, cell apoptosis, proliferation and migration ability caused by interfering with hsa_circ_0039933, indicating that HD-SB inhibited the expression of wnt11 through hsa_circ_0039933/hsa-miR-204-5p and exerted anti-tumor effect. The gene discussed is WNT11; the disease is neoplasm.