In GBM, the mRNA expression levels of TSPAN3/4/6/11/12/18/23/24/25/26/27/28/29/30/31 were significantly upregulated compared to those in normal tissues (Fig. 1A, p < 0.05), whereas the transcript levels of the remaining TSPAN family molecules were not significantly different. The gene discussed is TSPAN18; the disease is glioblastoma.