GO and pathway analysis applied to OCR predicted to be localized in both genic and intergenic RAD-specific enhancers revealed significant enrichment of genes related to chemical synaptic transmission in excitatory neurons, inhibitory neurons, and microglia notably Amyloid Beta Precursor Protein Binding Family A Member 2 (APBA2), that modulates AD amyloid precursor protein, and BDNF signaling pathway. This evidence concerns the gene BDNF and Alzheimer disease.