Twenty-nine genes were differentially expressed in tumor samples: 12 were upregulated (CD8A, BAX, EIF2AK3, HSP90AA1, CASP8, CALR, PDIA3, IFNG, FOXP3, NT5E, IL17A, and IFNB1), and 17 were downregulated (iIL6, TLR4, PRF1, IL1B, P2RX7, IFNGR1, CASP1, NLRP3, CD4, IL17RA, IL1R1, MYD88, IFNA1, TNF, ENTPD1, HMGB1, and PIK3CA) (Fig. 1A). This evidence concerns the gene HMGB1 and neoplasm.