PRF1 and neoplasm: Twenty-nine genes were differentially expressed in tumor samples: 12 were upregulated (CD8A, BAX, EIF2AK3, HSP90AA1, CASP8, CALR, PDIA3, IFNG, FOXP3, NT5E, IL17A, and IFNB1), and 17 were downregulated (iIL6, TLR4, PRF1, IL1B, P2RX7, IFNGR1, CASP1, NLRP3, CD4, IL17RA, IL1R1, MYD88, IFNA1, TNF, ENTPD1, HMGB1, and PIK3CA) (Fig. 1A).