CEACAM5 and diabetes mellitus: Additionally, there was no relation between studied parameters and other clinicopathological data (sex, smoking, diabetes mellitus, blood pressure) in non-cancer patients (P ˃ 0.05), while in CRC patients there were significant relations between circ-SAMARCA5 and blood pressure (P = 0.044), circ-RHOT1 and sex, smoking, diabetes mellitus, blood pressure (P = 0.042, 0.041, 0.045, 0.034 respectively) and between CEA and sex, smoking, lymph nodes (P = 0.003, 0.007,0.030 respectively) (Supplementary Tables 2–6).