Emerging research suggested that the aberrant expression of circRNAs contributes to the development of cancer, so this study aimed to detect the expression status of circ-SMARCA5, circ-NOL10, circ-LDLRAD3 and circ-RHOT1 in patients with CRC, and to explore their correlations with clinicopathological characteristics of the patients. The gene discussed is RHOT1; the disease is cancer.