Mechanisms by which miR-125 controls CRC form a complicated network, miR-125 could negatively modulate B cell lymphoma-2 like protein-12 (BCL2L12), B cell lymphoma-2 (BCL2), and myeloid cell leukemia-1 (Mcl-1), and down-regulated miR-125 promoted colon cancer cell proliferation and suppressed apoptosis23,24. This evidence concerns the gene BCL2L12 and colonic neoplasm.