CD4 and neoplasm: According to reports, specific tumor-infiltrating cells, such as CD8+ cytotoxic T lymphocytes, type 1 helper CD4+ T cells (Th1), M1 TAMs, and N1 TANs cells have anti-tumor activity, while T regulatory (Treg) cells, type 2 helper CD4+ T cells (Th2), N2 TANs cells and M2 TAMs known for their immunosuppressive and pro-tumor activity38,39.