ZFP36 and lung cancer: Based upon the abovementioned physic and functional interplay between ZFP36 and BARX1 in lung cancer tissues and NSCLC cell lines, we conclude that ZFP36 plays a suppressor role in NSCLC development by limiting the unscheduled accumulation of BARX1 mRNA, and the dysregulation of BARX1 during carcinogenesis is presumably attributable to the loss of ZFP36.