Based upon the abovementioned physic and functional interplay between ZFP36 and BARX1 in lung cancer tissues and NSCLC cell lines, we conclude that ZFP36 plays a suppressor role in NSCLC development by limiting the unscheduled accumulation of BARX1 mRNA, and the dysregulation of BARX1 during carcinogenesis is presumably attributable to the loss of ZFP36. The gene discussed is BARX1; the disease is lung cancer.