A study of genetic variants at 9q22 shows that the rs11789015-G allele markedly decreases the activity of the BARX1 promoter with lower levels of BARX1 mRNA and protein expression as compared with the A allele; however, there were no significant genotype-expression correlations for BARX1 expression in tumors and different genotypes of ESCC cell lines [17]. The gene discussed is BARX1; the disease is esophageal squamous cell carcinoma.