CDC45 and neoplasm: Next, we performed in silico prediction for the target genes of BARX1 (Supplementary File 2), among 86 target genes we identified, four master oncogenes have been shown to be drivers in tumor progression, including CDC20 (cell division cycle 20), CDC45 (cell division cycle 45), TRIM37 (tripartite motif containing 37) and MMP-9 (matrix metalloproteinase-9) which are involved in cell proliferation, migration and invasion, respectively.