Using a combination of amyloid misfolding status and GFAP levels, the incidence of Alzheimer's disease diagnosis could be accurately predicted 17 years in advance with a receiver-operating characteristic area under the curve of 0.83 (Beyer et al., 2022), paving the way for minimally invasive early detection of cognitive decline. The gene discussed is GFAP; the disease is early-onset autosomal dominant Alzheimer disease.