The promotion of immunogenic cell death by OVs, whose hallmark is the exposure of calreticulin to the cell surface, is key to the uptake of the dying tumor cells by DCs and subsequent induction of T-cells against tumor antigens.31 We found that our previously reported oncolytic VV (VVLΔTKΔN1L) was very effective in promoting exposure of calreticulin to the cell surface in a panel of human and murine TNBC cell lines (online supplemental figure S8) and to efficiently kill the mouse TNBC E0771.LMB cell line (online supplemental figure S9). Here, CALR is linked to neoplasm.