It is possible that oxygen tension and metabolic immunosuppression within the progressing tumor microenvironment could have suppressed Tetlo function as genes related to hypoxia and metabolic reprogramming such as Cnyp2 and Bckdhb were differentially expressed in Tetlo found in progressing tumors compared with those in the regressing tumors, and gene sets associated with metabolism adaptation, that is, non-coding RNA metabolic process pathway as well as regulation of ion transport and catabolic processes were significantly enriched. This evidence concerns the gene BCKDHB and neoplasm.