The impact of PCSK9 in other neurodegenerative diseases such as Parkinson’s disease, amyotrophic lateral sclerosis, multiple sclerosis, and Huntington’s disease with severe neuronal apoptosis has not been investigated despite the recognized association between lipid metabolism and the severity of these diseases (102, 103, 104, 105). The gene discussed is PCSK9; the disease is neurodegenerative disease.