Given that hyperglycemia and diabetes alone worsen ischemic strokes outcome in terms of prevalence, severity, and complications, and negatively impact on the integrity of the BBB, the initial hypothesis has been revisited: under acute hyperglycemic conditions, PCSK9 KO mice exhibit more intracerebral hemorrhages than wild-type mice following an MCAO procedure (79). The gene discussed is PCSK9; the disease is ischemic stroke.