In PE-treated dKO liver, there was no change in the level of TGFβ1 precursor (43 kDa), but collagen 1α1 was significantly reduced (Fig. 6A), suggesting that PE supplement–mediated reduction of TGFβ1 in the plasma could mitigate liver fibrosis. This evidence concerns the gene TGFB1 and Hepatic fibrosis.