SPNS1 and type 2 diabetes mellitus: Interestingly, while the burden of pLoF and predicted deleterious missense variants in ATXN2L (OR = 0.76; p = 0.011) and SPNS1 (OR = 0.89; p = 0.032) nominally decreased T2D risk, the singleton burden in SH2B1 nominally increased it (OR = 2.5; p = 0.028) (Table S10).