SH2B1 and type 2 diabetes mellitus: Seeking further evidence that changes in SH2B1 expression affect T2D, we performed colocalization analysis47 between the T2D GWAS signal and expression levels of the four genes with a significant TWMR effect but could not find any evidence of a shared causal variant (posterior probability of signal colocalisation [PP_H4] <0.387) (Table S14; STAR Methods).