Hepal-6-Luc cells expressing control (sgNC) or METTL3 knockout (sgMETL3) were implanted into the nonalcoholic steatohepatitis (NASH) livers of C57BL/6 mice, followed by treatment with anti-CD8α or immunoglobulin (Ig) G control. The gene discussed is GAN; the disease is metabolic dysfunction-associated steatohepatitis.