METTL3 and hepatocellular carcinoma: To this end, we inquired our in-house RNA sequencing (RNA-seq) database of 17 paired NAFLD-HCC and adjacent non-tumor tissues, revealing 2,028 genes that were overexpressed in NAFLD-HCC (fold change >1.5; p < 0.005), and METTL3 was one of the top RNA modification genes among the gene candidates (Figure 1A).