METTL3 and hepatocellular carcinoma: Notably, immune-related pathways, such as cytokine-cytokine receptor interaction, primary immunodeficiency, and chemokine signaling pathways, were significantly downregulated in Mettl3LKI tumors by gene set enrichment analysis (GSEA) (Figures 4A and S4A), implying that hepatocyte-specific METTL3 knockin reshapes immune microenvironment in NAFLD-HCC.