Notably, infiltration of GZMB+ and interferon gamma-positive (IFN-γ+) CD8+ T cells (clusters 0 and 4) was reduced in Mettl3LKI mice, suggesting hepatocyte-specific Mettl3 knockin inhibited cytotoxic CD8+ T activation in NAFLD-HCC (Figures 4F and 4G). This evidence concerns the gene GZMB and metabolic dysfunction-associated steatotic liver disease.