ITGAL and VEXAS syndrome: From a map of predicted target genes that were differentially expressed in HSPCs in VEXAS patients to a ligand-receptor activity heatmap (Figure 6E), ligand-receptor interactions between immune cells and HSPCs were consistent with upregulation of genes including STAT1, TNFAIP3, ITGAL, and GZMA involved in inflammation in HSPCs.