We enrolled two syngeneic murine tumor models (4T1/Balb-c BRCA model and MTCQ1-2/C57BL/6 HNSCC model) to reduce the influence of tumor-type-specific effect and treated the mice with control IgG, IL-10-Fc, αCSF-1R, or BF10. Here, IL10 is linked to head and neck squamous cell carcinoma.