Motor impairmentsin Parkinson’s disease can be ameliorated with D2R agonists,7 antipsychotic medications are either D2R antagonistsor weak partial agonists,8−10 and D2R is a putative targetfor treating addiction.11 Nevertheless,D2R medications have several features that lower the clinical efficacy,quality of life, and medication compliance. The gene discussed is DRD2; the disease is Parkinson disease.