For patients without DM, older age (HR 1.063 [1.031-1.096], P<0.001), increased Ang-2/Ang-1 ratio at ICU admission (HR: 4.515 [1.803-11.308] P=0.001), and need for dialysis (HR: 3.489 [1.409-8.642]; P=0.007) were independent predictors of death (Table 4). This evidence concerns the gene ANGPT2 and diabetes mellitus.