IL‐1β is a well‐established and validated pathway that plays a critical role in inflammatory lung injury.[26] Since we have detected the increased release of IL‐1β induced by circulating mt‐DAMPs (mtDNA and Formyl peptide) in the current study, the association between mt‐DAMPs, IL‐1β release and pre‐metastatic niche formation after osteosarcoma surgeries were further investigated. Here, IL1B is linked to osteosarcoma.