Interestingly, the KEGG results for miRNAs and MME-related proteins showed enrichment of the “FoxO signaling pathway” and “PI3k-Akt signaling pathway” in both analyses, indicating the important role of the PI3K/AKT/FOXO signaling pathway in the pathogenesis of SLE and BRCA (S3C Fig). This evidence concerns the gene AKT1 and systemic lupus erythematosus.