MAPK1 and early-onset autosomal dominant Alzheimer disease: It has been shown to directly regulate the amyloid-β precursor protein (APP) and Ran-binding protein 9 (RanBP9) as well as MAPK1, which are all implicated in the pathology of Alzheimer’s disease (Long and Lahiri 2011; Barbato et al. 2014; Li et al. 2019).