In addition, it was upregulated in the hippocampus of Alzheimer disease patients where it acts on ADAM10 (Akhter et al. 2018) and it seems to be a biomarker for cellular senescence (Gullett et al. 2020) as well as for several neurodegenerative diseases (Nguyen et al. 2022). Here, ADAM10 is linked to Alzheimer disease.