This overexpression increases the uptake of glucose by muscle tissue and activated the PI3K/Akt-1 pathway [44] by upregulating Akt-1 expression [45], which in turn leads to a decline in the expression levels of Foxo-1 and Pdk-4 [46] to counteract the excess of glucose and inhibit the insulin resistance. Here, FOXO1 is linked to Insulin resistance.