GPR176 and carcinoma of esophagus: In the xiantao platform, we conducted an analysis of genes differentially expressed between the low and high GPR176 mRNA expression groups in oesophageal cancer, and constructed a volcano map as shown in Fig. 3A. KEGG analysis revealed that the top signal pathways included protein digestion and absorption, extracellular matrix constituent, catenin complex, endoplasmic reticulum lumen and endopeptidase activity (Fig. 3B, p < 0.05).