Reportedly, chemoresistance of colorectal cancer cells was produced by LPCAT2-mediated lipid droplet formation (Cotte et al. 2018), which was also aided by prothymosin α (Jin et al. 2021), and metastasis-associated in colon cancer (Duan et al. 2017) through SREBP-1- and FASN-mediated lipogenesis respectively. Here, SREBF1 is linked to malignant colon neoplasm.