Other metabolite-related GPRs, including lactate receptor (GPR81) (Brown et al. 2020), succinate receptor‐1 (GPR91) (Kuo et al. 2022), neurokinin-1 receptor (Zhang et al. 2022), and purinergic receptor (Wang et al. 2020), were extensively investigated in cancer research. The gene discussed is P2RY2; the disease is cancer.