RUNX1 and Zika virus infectious disease: We selected iPSC-derived macrophages as a model to study the effect of hypoxia on ZIKV infection as they also develop in an MYB-independent, runt-related transcription factor 1 (RUNX1)-, and Spleen Focus Forming Virus (SFFV) Proviral Integration Oncogen (SPI1)-dependent fashion and provide a model for MYB-independent tissue-resident macrophages [24].