Skeletal muscle homeostasis is important for systematic metabolic improvements (Pedersen & Febbraio, 2012; Sartori et al., 2021) by increasing insulin sensitivity, reducing lipid dysregulation, enhancing basal metabolic rate and improving hepatic steatosis (Al Saif & Alsenany, 2015; Gundersen, 2011; Rodriguez‐Fdez et al., 2020). The gene discussed is INS; the disease is fatty liver disease.