Of note, compared to PGC‐1α1, which is mainly induced in response to endurance exercise, PGC‐1α4, a short isoform of PGC‐1α, is strongly induced in muscle under resistance training and promoted muscle hypertrophy in both basal condition and in muscle atrophic scenarios, that is, hindlimb suspension and cancer‐induced cachexia, possibly via histone modifications of its target genes including Igf1 and myostatin in nucleus (Ruas et al., 2012; White et al., 2014). This evidence concerns the gene MSTN and Cachexia.