APC and neoplasm: Multivariable logistic regression correcting for age, timing of metastasis, tumor volume, and ISUP grade further proved this association to be robust (TP53, adjusted HR: 0.3, 95% CI: 0.18–0.49, q < 0.001; PTEN, adjusted HR = 0.19, 95% CI: 0.08–0.48, q = 0.006; APC, adjusted HR = 0.15, 95% CI: 0.05–0.48, q = 0.01, Table S10).