FOXO‐1, FOXO‐3, and FOXO‐4 are partially redundant tumor suppressors that induce pro‐apoptotic genes such as TRAIL and cell cycle inhibitors such as cyclin‐dependent kinase inhibitor 1B (CDKN1B; encoding p27) in some settings [19, 20]. This evidence concerns the gene CDKN1B and neoplasm.