PIK3CA and breast cancer: Meanwhile, PIK3CA mutation is one of the most common mutations in solid tumors, especially in endometrial (42–55%) (Travaglino et al., 2022); PIK3CA mutation is one of the most common mutations in solid tumors, especially in endometrial (42–55%) (Kandoth et al., 2013), cervical (42%) (The Cancer Genome Atlas Research Network, 2017), breast cancer (27–36%).