HIF-1α is known to play an important role in hypoxia-induced angiogenesis, metastasis (Xing et al., 2011; Bocca et al., 2014), EMT and invasion of cancer cells (Jo et al., 2009; Xing et al., 2011; Bocca et al., 2014; Zhang et al., 2021; Zhang et al., 2022), and also in inducing conventional drug-resistant properties (Yu et al., 2012), thus playing a central role in tumor cell malignancy. This evidence concerns the gene HIF1A and cancer.