Moreover, the role of the transcription factor NF-κB as a controlling factor in inflammation and metastasis of the TME of CRC is well-studied and established (Oliveira et al., 2015; Tyagi et al., 2017; Buhrmann et al., 2019; Buhrmann et al., 2020a; Buhrmann et al., 2020b), but little is known about HIF-1α in this context. This evidence concerns the gene HIF1A and colorectal carcinoma.