Interestingly, CRC cell migration and invasion were also promoted by angiogenesis-supporting transcription factor ‘hypoxia-inducible factor’ (HIF)-1α (Kim et al., 2017), which is, in turn, initiated by the inflammatory NF-κB-activated milieu in a tumor microenvironment (TME) (Buhrmann et al., 2020c). Here, HIF1A is linked to colorectal carcinoma.