However, oral administration of LA immediately before glucose load did not promote insulin secretion in response to the elevation of postprandial glucose level in normal rats (Figure 1C), and it decreased the postprandial glucose levels by 30 min after glucose load in the most severe T1DM model rats, whose ability to secrete insulin in response to the elevating glucose level was impaired by streptozocin (Figure 1D). This evidence concerns the gene INS and type 1 diabetes mellitus.