Previous clinical studies of T1DM indicated that the administration of rapid-acting insulin analogs immediately before meals resulted in the postprandial blood glucose level being higher than 180 mg/dL, and this administration 15 or 20 min before meals kept postprandial blood glucose levels under 180 mg/dL (Cobry et al., 2010; Luijf et al., 2010). Here, INS is linked to type 1 diabetes mellitus.