VEGFA and COVID-19: CEP exhibited a strong binding force with phosphatidylinositol 3-kinase (PIK3) CA, PIK3CD, AKT serine/threonine kinase 1 (AKT1), and ACE2 and plays a significant role in the treatment of COVID-19 by regulating PI3K-Akt, relaxin, vascular endothelial growth factor (VEGF), and HIF-1 signaling pathways (Jiang et al., 2022).