Our study conducted Cox regression analysis, which revealed that cancers with high expression of NQO1, including glioma, uveal melanoma, head and neck squamous cell carcinoma, kidney renal papillary cell carcinoma, adrenocortical carcinoma, and pan-kidney cohort, had significantly higher hazard ratios for OS (Supplementary Figure S5A). This evidence concerns the gene NQO1 and head and neck squamous cell carcinoma.