Additionly, NQO1 and NRF2 are known to be associated with ferroptosis in tumors (Liu et al., 2022; Shan et al., 2020; Zheng et al., 2022), neurodegenerative diseases (Yang et al., 2022), amyotrophic lateral sclerosis (Peng et al., 2022). This evidence concerns the gene NQO1 and amyotrophic lateral sclerosis.