The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis showed that NQO1 co-expressed genes were related to fluid shear and atherosclerosis, folate biosynthesis, metabolic pathways, pathways in cancer, ferroptosis, hepatocellular carcinoma, amyotrophic lateral sclerosis, glutathione metabolism, steroid hormone biosynthesis, proteoglycans in cancer (Figure 6B), where fluid shear stress and atherosclerosis, pathways in cancer, and hepatocellular carcinoma are consistent with NRF2-associated gene enrichment pathways (Supplementary Table S2). This evidence concerns the gene NQO1 and amyotrophic lateral sclerosis.