Unlike NQO1, NRF2 was differentially expressed from controls in adrenocortical carcinoma, kidney renal papillary cell carcinoma, brain lower grade glioma, and thyroid carcinoma, but not in cervical squamous cell carcinoma and endocervical adenocarcinoma, colon adenocarcinoma, kidney renal papillary cell carcinoma, pheochromocytoma and paraganglioma, and rectum adenocarcinoma. Here, NQO1 is linked to hereditary pheochromocytoma-paraganglioma.